Triple Negative Invasive Ductal Carcinoma of Breast with Oral Metastasis: A Case Report
Published: May 1, 2023 | DOI: https://doi.org/10.7860/JCDR/2023/61996.17951
Sabaritha Ramamoorthy, Prasanth Thankappan, Isaac Joseph Tharmasahayam, Jeslin Mary Samraj, Evelyn Angel Stephen
1. Postgraduate, Department of Oral Pathology, Sree Mookambika Institute of Dental Sciences, Kanyakumari, Tamil Nadu, India.
2. Professor, Department of Oral Pathology, Sree Mookambika Institute of Dental Sciences, Kanyakumari, Tamil Nadu, India.
3. Professor and Head, Department of Oral Pathology, Sree Mookambika Institute of Dental Sciences, Kanyakumari, Tamil Nadu, India.
4. Assistant Professor, Department of Oral Pathology, Sree Mookambika Institute of Dental Sciences, Kanyakumari, Tamil Nadu, India.
5. Associate Professor, Department of General Pathology, Sree Mookambika Institute of Dental Sciences, Kanyakumari, Tamil Nadu, India.
Correspondence
Prasanth Thankappan,
Professor, Department of Oral Pathology, Sree Mookambika Institute of Dental Sciences, Kulasekharam, Kanyakumari, Tamil Nadu, India.
E-mail: prasantht2020@gmail.com
Metastatic oral malignancies have been reported in the mandible, tongue, and gingiva. Oral metastasis of breast cancer typically presents as a benign oral lesion clinically. However, at histology, it shares several features with metastatic carcinoma, and Immunohistochemistry (IHC) can be useful in the differential diagnosis. The clinical presentation in this case report consisted of swelling in the upper front tooth region in a 35-year-old woman. The lesion was excised under local anaesthesia and underwent histological and immunohistochemical examination to rule out any malignancy. The histological findings, including Pan CK positivity suggesting an epithelial origin and the absence of reactivity to Oestrogen Receptor (ER), Progesterone Receptor (PR), and Human Epidermal Growth Factor Receptor-2 (HER2) indicated metastatic triple negative breast carcinoma. The histological diagnosis of metastatic breast carcinoma can be confirmed by IHC. The current case report illustrates the necessity of including a panel of IHC markers in confirming the diagnosis of metastatic lesions in oral cavity. By utilising such panels, one can expedite the prognosis and prevent delay in diagnosis.
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